|
Crohn Disease
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
ATG16L1 and LC3 expression was analyzed in the inflamed ileum and colon of 28 patients with Crohn's disease (CD), 14 with ulcerative colitis (UC) and 23 controls by western blot.
|
27335178 |
2016 |
|
Crohn Disease
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
CD-associated polymorphisms affected the elimination of MAP from ex vivo monocytes (NOD2), or expression of certain cytokines (ATG16L1), implying independent but contributory roles in the pathogenesis of CD.
|
21734790 |
2011 |
|
Crohn Disease
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We investigated the role of the microRNAs (miRs) MIR106B and MIR93 in induction of autophagy and bacterial clearance in human cell lines and the correlation between MIR106B and autophagy-related gene 16L1 (ATG16L1) expression in tissues from patients with CD.
|
24036151 |
2014 |
|
Ulcerative Colitis
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
ATG16L1 and LC3 expression was analyzed in the inflamed ileum and colon of 28 patients with Crohn's disease (CD), 14 with ulcerative colitis (UC) and 23 controls by western blot.
|
27335178 |
2016 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Overexpression of ATG16L1 was significantly associated with disease stage (p = 0.001), size (p = 0.031) of the tumor, lymph node metastasis (p = 0.004), and histological grade (p = 0.038).
|
25060858 |
2015 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
Conversely, expression of ATG16L1 in epithelial cancer cells inhibited tumor growth, indicating that the effects of autophagy are compartment-specific.
|
22684298 |
2012 |
|
Neoplasms
|
0.080 |
AlteredExpression
|
group |
BEFREE |
ATG16L1 gene expression was detected in both tumor and peritumoral tissues, with the mRNA-ATG16L1 levels significantly higher in tumor sample.
|
26547861 |
2016 |
|
Liver carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Thus, peretinoin prevents the progression of NASH and the development of HCC through activating the autophagy pathway by increased Atg16L1 expression, which is an essential regulator of autophagy and anti-inflammatory proteins.
|
28591717 |
2017 |
|
Ileitis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The transcriptional regulation of ATG16L1 was studied in intestinal epithelial cells following stimulation with Toll-like receptor (TLR) ligands and proinflammatory cytokines and in a murine ileitis model and CD biopsies.
|
18162085 |
2008 |
|
Medulloblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
HIF1A is Overexpressed in Medulloblastoma and its Inhibition Reduces Proliferation and Increases EPAS1 and ATG16L1 Methylation.
|
28302031 |
2018 |
|
melanoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We examined five single-nucleotide polymorphisms (SNPs) in three ATG genes (ATG5; ATG10; and ATG16L) with known or suspected impact on autophagic flux in an international population-based case-control study of melanoma.
|
27748080 |
2016 |
|
Osteosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MicroRNA-410 regulates autophagy-related gene ATG16L1 expression and enhances chemosensitivity via autophagy inhibition in osteosarcoma.
|
28138700 |
2017 |
|
Status Epilepticus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found that Atg7 and Atg16L1 were up-regulated in the neurons after SE, together with an increase in autophagosome formation.
|
28860495 |
2017 |
|
Childhood Medulloblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
HIF1A is Overexpressed in Medulloblastoma and its Inhibition Reduces Proliferation and Increases EPAS1 and ATG16L1 Methylation.
|
28302031 |
2018 |
|
Adult Medulloblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
HIF1A is Overexpressed in Medulloblastoma and its Inhibition Reduces Proliferation and Increases EPAS1 and ATG16L1 Methylation.
|
28302031 |
2018 |
|
Osteosarcoma of bone
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MicroRNA-410 regulates autophagy-related gene ATG16L1 expression and enhances chemosensitivity via autophagy inhibition in osteosarcoma.
|
28138700 |
2017 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of ATG16L1 was significantly associated with disease stage (p = 0.001), size (p = 0.031) of the tumor, lymph node metastasis (p = 0.004), and histological grade (p = 0.038).
|
25060858 |
2015 |
|
Childhood Osteosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MicroRNA-410 regulates autophagy-related gene ATG16L1 expression and enhances chemosensitivity via autophagy inhibition in osteosarcoma.
|
28138700 |
2017 |
|
Fatty Liver Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Decreased Atg16L1 mRNA expression was also found in the liver of patients with NASH according to disease progression.
|
28591717 |
2017 |
|
Sporadic Parkinson disease
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Genetic analysis of the ATG16L1 gene promoter in sporadic Parkinson's disease.
|
28279708 |
2017 |
|
Cardiomegaly
|
0.200 |
Therapeutic
|
phenotype |
RGD |
Aliskiren ameliorates pressure overload-induced heart hypertrophy and fibrosis in mice.
|
24998254 |
2014 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
ATG16L1 and TNFSF15 are associated with CD in Taiwan.
|
21930071 |
2011 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
ATG16L1, a protein essential for early stages of autophagy, has been implicated in the pathogenesis of Crohn's disease.
|
25767270 |
2015 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Role of ATG16L, NOD2 and IL23R in Crohn's disease pathogenesis.
|
22346247 |
2012 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
IRGM, NOD2, and ATG16L1, all of which are Crohn's disease risk factors, form a molecular complex to modulate autophagic responses to microbial products.
|
25891078 |
2015 |